MOLECULAR AND CELLULAR MEDICINE RESEARCH GRANT: SEP 2021

1. Title: MOLECULAR AND CELLULAR MEDICINE RESEARCH GRANT: SEP 20212. Awarding Authority: Medical Research Council (MRC), GB. Web: 3. Contract type: Service contract4. Description: Funding is available from the awarding authority’s Molecular and Cellular Medicine Board to support focused research projects on molecular and cellular medicine.We award research grants to UK-based research organisations. Research grants may involve more than one research group or institution.There is no limit to the funding you can request, but it should be appropriate to the project. Typically awards are up to £1 million. We will usually fund up to 80% of your project’s full economic cost.Projects can last up to five years and are typically three to four years.What we’re looking forThe MRC’s Molecular and Cellular Medicine Board funds research into basic biological mechanisms or technologies relevant to human health and disease.We aim to increase understanding of:the structure and function of molecules and complexesthe cellular environment during development and mature stateshow biological systems respond to challenges (for example, drugs and toxins) and diseases.We lead MRC’s investments in cancer, from fundamental discovery science to epidemiology, experimental medicine and early translation. Research focused on specific organ systems or diseases (with the exception of cancer and haematology) is normally supported through our other research boards.Research we fund includes, but is not limited to, the following areas:cell biologystructural biology and biophysicsmolecular and functional genetics, epigenetics, genomicsdevelopmental and stem cell biology (excluding neurobiology)regenerative medicinemolecular haematologydevelopment of new tools and technologies relevant to MCMB remit, such as:nanotechnology, chemical biology and synthetic biologymedical bioinformatics (including biostatistics, computational biology and systems biology)cancertoxicology and adverse health effects of environmental exposurespharmacology.Find out more about the science areas we support and our current board opportunity areas (MRC website).We encourage you to contact us first to discuss your application, especially if you believe your research may cross MRC research board or research council interests. If your application fits another research board remit better we may decide to transfer it there to be assessed.MRC molecular and cellular medicine research grants:are suitable for focused short or long-term research projectscan support method development or development and continuation of research facilitiesmay involve more than one research group or institution.We will fund projects lasting up to five years, although projects typically last three to four years. If your project will last more than three years, you must justify the reason for this. For example, if you need time for data collection or follow-up.If your project will last less than two years, it must be for proof of principle or pilot work only. We expect proof of principle proposals to support high-risk or high-reward research by critically testing a key hypothesis or demonstrating feasibility of an approach that could lead to fundamentally new avenues of research.Contact one of our programme managers for advice if you would like to apply for a short or long-duration project.You can request funding for costs such as:a contribution to the salary of the principal investigator and co-investigatorssupport for other posts such as research and technicalresearch consumablesequipmenttravel costsdata preservation, data sharing and dissemination costsestates/indirect costs.We will not fund:research involving randomised trials of clinical treatmentsfunding to use as a ‘bridge’ between grantscosts for PhD studentshipspublication costs.5. CPV Code(s): 73110000, 73100000, 73000000, 73220000, 851400006. NUTS code(s): UKK, UKK1, UKK147. Main site or location of works, main place of delivery or main place of performance: South West (England), Gloucestershire, Wiltshire And Bristol/Bath Area, Swindon.8. Reference attributed by awarding authority: Not provided.9. Estimated value of requirement: Not provided.10. Closing Date: 1.9.2021 (16:00:00).11. Address to which they must be sent: For further information regarding the above contract notice please visit:12. Other information: Who can applyAny UK-based researcher with an employment contract at an eligible research organisation can apply. You will need to:have at least a graduate degree, although we usually expect most applicants to have a PhD or medical degreeshow that you will direct the project and be actively engaged in the work.You can include one or more industry partners as project partners in your application. International co-investigators can be included if they provide expertise not available in the UK.The focus of this funding opportunity is molecular and cellular medicine research. There are similar opportunities across other areas of medical research within our remit (MRC website), including:population and systems medicineinfections and immunityneurosciences and mental healthapplied global health.There are also other types of awards, including:programmespartnershipsnew investigator.You should contact us if you are not sure which opportunity to apply to.How to applyApplication deadlines for Molecular and Cellular Medicine Board funding are usually around January, May and September, although sometimes dates can change, so check the funding finder for details.You can submit to any of the available deadlines in the year. We do not expect you to submit more than two applications at the same time and encourage you to focus on application quality, not the number you can submit. For details of our resubmission process, read our guidance for applicants (MRC website).Applying through Je-SYou must apply through the Joint Electronic Submission system (Je-S).For more information, please read the Je-S how to apply guidance (PDF, 190KB).If you need help in applying, you can contact Je-S on 01793 444164 or by email jeshelp@je-s.ukri.org.You should give your administrative department sufficient notice that you intend to apply. Your organisation must submit your application before 16:00 on the deadline date.When applying select:council: MRCdocument type: standard proposalscheme: research grantcall/type/mode: research boards September 2021 submissions.Indicating the proposal is a research grantSelect the ‘grant type’ option from the proposal document menu, within the Je-S proposal form. Within the section, select the radio button adjacent to the ‘research grant’ option and select the ‘save’ button.Guidance for applicantsOur guidance for applicants (MRC website) will:help you check your eligibilityguide you through preparing a proposalshow you how to prepare a case for supportprovide details of any ethical and regulatory requirements that may apply.Industrial partnersIf you want to include one or more industry partners as a project partner, you must also:complete the project partner section in Je-Ssubmit an MRC industrial collaboration agreement (MICA) form and heads of termsinclude ‘MICA’ as a prefix to your project title.Find out more about MRC industry collaboration agreements (MRC website).How we will assess your applicationWhen we receive your application, it will be peer-reviewed by independent experts from the UK and overseas.You can nominate up to three independent reviewers. We will invite only one to assess your application and may decide not to approach any of your nominated reviewers.Peer reviewers will assess your application and provide comments. They will also score it using the peer reviewer scoring system against the following criteria:importance: how important are the questions, or gaps in knowledge, that are being addressed?scientific potential: what are the prospects for good scientific progress?resources requested: are the funds requested essential for the work? And do the importance and scientific potential justify funding on the scale requested? Does the proposal represent good value for money?Read the detailed assessment criteria (MRC website).We will review these scores and comments at a triage meeting and expect to continue with the highest-quality applications with potential to be funded. If your application passes the triage stage, we will give you the chance to respond to reviewers comments.A board meeting will then discuss your proposal and decide if it is suitable for funding.We make a decision within six months of receiving your application.Find out more about our peer review process (MRC website).Contact detailsGet advice on your application or choosing a boardEmail: mcmb@mrc.ukri.orgOr contact the programme manager most relevant to your research area:Cell biology, developmental biology and the physical science interfaceDr Holger ApitzEmail: holger.apitz@mrc.ukri.orgStructural studies and biophysicsDr Anne McGaviganEmail: anne.mcgavigan@mrc.ukri.orgGenomics, gene regulatory networks and synthetic biologyDr Tim CullingfordEmail: tim.cullingford@mrc.ukri.orgEnvironmental health, pharmacology and toxicologyDr Graham CampbellEmail: graham.campbell@mrc.ukri.orgCancerDr Mariana Delfino-MachinEmail: mariana.delfino-machin@mrc.ukri.orgRegenerative medicineDr Charlotte DurkinEmail: charlotte.durkin@mrc.ukri.orgSee our science and contactsGet help with using Je-SContact Je-S Helpdesk.Email: jeshelp@je-s.ukri.orgTelephone: 01793 444164Discuss MRC policy and eligibilityContact our research funding policy and delivery team.Email: rfpd@mrc.ukri.orgTelephone: 01793 416440Additional infoSupporting documents on the website above.TKR-2021329-EX-1583222# funding opportunity