PAIN RESEARCH DATA HUB SPF ADVANCED PAIN DISCOVERY PLATFORM – FUNDING

1. Title: PAIN RESEARCH DATA HUB SPF ADVANCED PAIN DISCOVERY PLATFORM – FUNDING2. Awarding Authority: Medical Research Council (MRC), Economic and Social Research Council (ESRC), Biotechnology and Biological Sciences Research Council (BBSRC), UKRI, Versus Arthritis, Eli Lilly and Company UK, GB Tel: 01793 44 4164. Email: JeSHelp@rcuk.ac.uk / david.walsh@mrc.ukri.org / david.walsh@mrc.ukri.org. (Prof. David Walsh, APDP Director)3. Contract type: Service contract4. Description: Apply for funding to set up a pain research data hub.The hub will be part of the awarding authority and Versus Arthritis Strategic Priority Fund (SPF) Advanced Pain Discovery Platform. It will underpin original research by providing innovative new data assets for pain research in areas of need. It will not support original research directly.You must be a UK research organisation eligible for Medical Research Council funding. This includes:higher education institutionsapproved independent research organisationsapproved NHS bodiesresearch council institutes.Your proposal must show:appropriate scientific and clinical leadershipa track record of using health data for public benefitthe ability to process health data for research and innovationa commitment to patient and public involvement.Funding is available for the development of one hub over three years. We’ll cover 67% of the full economic costs.We expect the hub to develop into an ongoing national resource for pain research.5. CPV Code(s): 73110000, 73100000, 730000006. NUTS code(s): UKK, UKK1, UKK147. Main site or location of works, main place of delivery or main place of performance: UK8. Reference attributed by awarding authority: Not provided.9. Estimated value of requirement: Total fund: £2,000,000Maximum award: £2,000,00010. Closing date: 25.2.2021 (16:00).11. Address to which they must be sent: For further information regarding the above contract notice please visit:12. Other information: Opportunity status:OpenFunding type: GrantWho can applyThis funding opportunity is open to applicants from eligible UK-based organisations in accordance with standard UKRI and Versus Arthritis practice.See more details on institutional and individual eligibility.Applications must demonstrate:appropriate scientific and clinical leadershipa track record of the use of health data for public benefitthe ability to process health data for research and innovationthat the hub will deliver a national?service that will be financially sustainable in the long-term.Recognising the value of regional data sets and leadership it is expected that proposals involve multi-institutional collaboration. However, proposals must be submitted by a single lead organisation.Institutions may be partners to more than one application but should only act as the lead institution for one.At least one member of the partnership must have a demonstrable track record in acting as a data custodian with the ability to make data accessible for research, development and innovation taking place across academia, industry and the NHS.We strongly encourage collaboration across sectors, including NHS organisations, academia, industry and other partners. Collaborations with industrial partners should be managed through an MRC industry collaboration agreement.You can also include international co-investigators if they provide expertise that is not available in the UK. We expect a demonstrable commitment to patient involvement in the development and implementation of the data hub.The pain research data hub is expected to start before 1 June 2021.How to applyPlease email the intention to submit form found below to spfpain@mrc.ukri.org by 16:00, 29 January 2021. This is mandatory. Proposals will not be accepted from applicants who have failed to provide an intention to submit.Please include the names of the principal investigators, co-investigators and any collaborating organisations confirmed at this stage. This is to help us manage conflicts at the panel assessment stage and will not involve any expert assessment.The full proposal should be submitted through Je-S by 16:00, 25 February 2021.The proposal should consist of a completed Je-S form and the following attachments:Case for support (maximum 12 sides A4)The case for support forms the main body of your proposal and should contain the following sections:an overview of the hub including its vision, goals, key partnerships and interfaces and expected outputsthe data sets to be included within the hub, describing the data sets that will be brought together under the APDP initiative and linked to the HDR UK Alliance over the course of the award and include the data custodians, modes and sizes of datasets (number of records, populations covered), the current quality of the data (coverage, completeness, validity, timeliness and accuracy) and the environment in which they are currently stored (process and governance for access)a description of why these data sets are particularly valuable for research and innovation and which data sets will be immediately ready to become part of the Alliance and discoverable through the Gateway, including the associated metadata to support discoverabilitya description of the technical infrastructure, including demonstrating that the level of security and Safe Haven capability that you host or have access to is appropriate for the data and services that the hub will be providingthe curation approach that you will be using to improve the quality of the data sets and what improvements these will enable, describing what new research and innovation uses will be created by this improvement in quality, supported by evidence for the demandthe expert services that will be provided in the hub and the distinct value that the hub will provide to academic users, industry, and other usersthe unmet demand for the curated data and services that the hub will provide should be clearly described, including how the hub will be driven by continuous assessment of user needspositioning in the wider landscape: how the proposed hub will add value to, and build on, existing investments and activities, describing how the services provided by the hub will be uniquely valuable, address a currently unmet need and provide additional capability over and above the existing components of the national data and pain research landscapedelivery feasibility and risk management, describing how the delivery milestones laid out in the above section will be met, supported by an overall project plan (Gantt Chart – separate attachment) and a discussion of the risks with mitigating actions. Describe the project management process that will provide assurance that the delivery milestones and goals will be achievedcapabilities and partnership. This section should describe the leadership team and key roles, including a named hub director and a named chief data officer. Each will be expected to have a track record of working with and across organisations and sectors to deliver common goals and objectives, and of building deep collaborative partnershipsdemonstrate the leadership team’s expertise and track record in governance, management systems and achieving outcomes at pace in clinical digital research and innovation. We recognise the diversity of skills necessary for a successful team and encourage proposals to recognise the contribution of technical professionalsthis section should also describe how clinical leadership will be a part of leadership and governance to ensure decisions on data and services are benefiting people with pain, the NHS and public. How the hub will harness the partnership capabilities to deliver outcomes that could not be achieved by a single organisationgovernance and management. Describe how the lead organisation will govern and manage the partnership and how the partnership will deliver to meet user timescale expectations. Describe the systems, processes and organisational behaviours in place to provide assurance that data will be secure and that all access will be appropriate, proportionate and subject to robust governance in line with National Data Guardian and Information Commissioner’s Office recommendationsthe partnership’s track record in engaging and involving members of the public, including those with lived experience of chronic pain, in health data research and the underpinning data services. The partnership’s plan for public and patient involvement and engagement, detailing how people with pain will be involved in governance of the hub, including developing systems for and decisions about access to, use and security of patient datathe outreach plans of the hub to facilitate impact and drive improvement of the hub through user feedbackhow the hub will work in partnership with other hubs in the HDR UK network and other components of the national data infrastructure to deliver a national offer in line with the HDR UK’s principles for participationthe physical environment the partnership will provide as a hub base to support collaboration and innovations across a range of users (for example data scientists, clinicians) from industry, the NHS and academiayour plan for sustainability of the hub (through, for example, a robust portfolio of grant funding, service charges, commercial funding) while continuing to adhere to the principles for participation and a commitment to open access of methodologies, code and findings.Contact detailsIf you have a query about the scientific aspects of your proposal, please contact awarding authrityFor queries regarding the direction of the APDP, please contact awarding authority# funding opportunity