ADCs for Therapeutic Evaluation

Type of document: Contract Notice
Country: United Kingdom

ADCS FOR THERAPEUTIC EVALUATION
Single stage – Any candidate may submit a tender.
Contract type: Supply contract
Contracting authority: Swansea University, Swansea University Medical School (SUMS), Procurement – Finance, Swansea University, Singleton Park, Swansea, SA2 8PP. Tel: 01792295890. Web: www.swansea.ac.uk Electronic access to information: Electronic submission of tenders and requests to participate: (Alan Davies), SA2 8PP.
Object of the contract
Bridgend and Neath Port Talbot
Swansea.
The awarding authority require the Phase 1 development of antibody drug conjugates using two IgG1 murine monoclonal antibodies provided by SUMS to be conjugated to monomethyl auristatin E (MMAE) as payload using an appropriate state of the art linker technology. Following provision of 5mg of Phase 1 ADCs SUMS will evaluate and select the lead candidate for further testing. Upon successful outcome of Phase 1 assessment there will be a requirement for a Phase 2 sytnthesis involving the provision of 200mg of one SUMS selected ADC. If Phase 1 is unsuccessful as determined by evaluation by SUMS, Phase 2 will not be entered into. In addition SUMS require the provision of 12 mg of an isotype control ADC and an Alexa 750 conjugate to the selected SUMS antibody for use in bio-distribution studies. Finally SUMS may require additional small and large scale synthesis over the next 48 months for new IgG1 antibodies.
It is expected that the vendor will have a proven record of successful ADC production to standards required for in vivo assessments. In addition the vendor will need to demonstrate the capability for in house ADC assessment and meeting certified safety standards for toxin handling.
CPV: 33600000, 33651500, 85149000
Administrative Information
WA Ref:80076
Reference number attributed to the notice by the contracting authority
T42(18)
Time-limit for receipt of completed tenders 17.4.2018 (12:00:00)
For further information/documentation regarding the above contract notice please visit
Other Information
NOTE: The authority is using eTenderwales to carry out this procurement process. To obtain further information record your interest on Sell2Wales at
Total quantity or scope of tender
Successful outcome of Phase 1 will lead to contracting for ongoing ADC provision over a period of 4 years.
Minimum standards and qualification required
All correspondence relating to this tender project must be via the e-tender Wales message board.
Estimated award date
27-04-2018
Language or languages in which tenders or requests to participate can be drawn up
EN
Welsh/Cymraeg
Additional Information
(WA Ref:80076)
Relates to the following project/programme financed by EU Community Funds: Initial funding will include AgorIP although other funding streams may be used for this contract.
The buyer considers that this contract is suitable for consortia bidding.
TKR-2018330-EX-716242